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. 1984;79(2):441-5.
doi: 10.1016/0742-8413(84)90228-7.

The effect of pentylenetetrazol on spike broadening and potassium inactivation

D Doerner, R M Pacheco, L D Partridge, M F Pacheco

The effect of pentylenetetrazol on spike broadening and potassium inactivation

D Doerner et al. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984.

Abstract

The effect of the convulsant drug, pentylenetetrazol (PTZ) on spike broadening and potassium current inactivation was studied. PTZ was found to decrease the time taken for a cell to reach maximal broadening as well as causing a decrease in the total amount of broadening. Voltage clamp studies showed that in the presence of PTZ potassium current inactivated less but exhibited a faster time constant of inactivation. By exerting an effect on potassium inactivation and thereby spike broadening, PTZ may alter synaptic efficacy. Such an effect on synaptic efficacy may partially underlie the drug's convulsive activity.

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