5-HT1 receptor sites and functional correlates

Abstract

Radioligand techniques have identified at least two distinct serotonergic binding sites in the central nervous system; "5-HT1" sites have high affinity for serotonin and related agonists and low affinity for serotonergic antagonists. Similar pharmacological properties are present in a number of physiological systems, including stimulation of adenylate cyclase, inhibition of neurotransmitter release and contraction of certain arterial systems. The correlation between binding data and physiological functions allows these sites to be designated "5-HT1 receptors".