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. 1980 Jan 10;283(5743):162-7.
doi: 10.1038/283162a0.

Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones

P J Davies, D R Davies, A Levitzki, F R Maxfield, P Milhaud, M C Willingham, I H Pastan

Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones

P J Davies et al. Nature. .

Abstract

The receptor-mediated endocytosis of alpha 2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.

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