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. 1980 Apr;77(4):1862-6.
doi: 10.1073/pnas.77.4.1862.

Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12

R P Lawther, G W Hatfield

Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12

R P Lawther et al. Proc Natl Acad Sci U S A. 1980 Apr.

Abstract

The regulatory region for the ilvGEDA operon of Escherichia coli K-12 has been located and characterized. ilv leader RNA transcribed from this region is described, and the DNA sequence of the region is presented. This DNA sequence contains a transcription promoter, a region coding for a 32-amino-acid polypeptide containing multiple isoleucine, valine, and leucine codons, and a transcription termination site preceding the first structural gene. The mutually exclusive secondary structures of the leader RNA have been analyzed. On the basis of these data, a model for the multivalent attenuation of the ilvGEDA operon is proposed.

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