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. 1980 Mar;10(3):224-5.
doi: 10.1002/eji.1830100312.

Dissociation between interferon production induced by phytohemagglutinin and concanavalin A in spleen cell cultures of nude mice

H Kirchner, H Fenkl, R Zawatzky, H Engler, H Becker

Dissociation between interferon production induced by phytohemagglutinin and concanavalin A in spleen cell cultures of nude mice

H Kirchner et al. Eur J Immunol. 1980 Mar.

Abstract

Spleen cells of homozygous nude mice did not react with lymphoproliferation to both phytohemagglutinin (PHA) and concanavalin A (Con A), and there was no detectable interferon production in response to Con A. However, PHA-induced interferon production was equal in spleen cells of nu/nu mice and nu/+ mice. One possible explanation for these findings is that a subset of T cells responds to PHA with interferon production different from that responding to Con A with interferon production.

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