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Comparative Study
. 1980 Feb;27(2):449-54.
doi: 10.1128/iai.27.2.449-454.1980.

Mucin model for group B type III streptococcal infection in mice

D O Fleming
Comparative Study

Mucin model for group B type III streptococcal infection in mice

D O Fleming. Infect Immun. 1980 Feb.

Abstract

An experimental murine infection was established by the intraperitoneal injection of a log-phase culture of a laboratory reference strain of Streptococcus agalactiae, Lancefield group B, type III (strain SS620), suspended in sterile hog gastric mucin. The enhancement of streptococcal virulence was measured by a significantly increased mortality in outbred ICR Swiss mice. An inbred C57BL6 strain of mice was resistant to the mucin-bacterial combination. Mucin, treated with Desferal to chelate the iron, did not lose the capacity to enhance the virulence of group B, type III streptococci in ICR Swiss mice. Iron-dextran was not a suitable substitute for mucin and failed to enhance the virulence of group B, type III streptococci. The results of these studies indicate that iron is not the resistance-lowering factor in this group B, type III streptococci-mucin model.

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