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. 1980;223(2):135-46.
doi: 10.1007/BF00313176.

Neurochemical changes in Creutzfeldt-Jakob disease

A Federico, P Annunziata, G Malentacchi

Neurochemical changes in Creutzfeldt-Jakob disease

A Federico et al. J Neurol. 1980.

Abstract

A biochemical study of a case affected by Creutzfeldt-Jakob disease is reported. Changes were found in soluble and insoluble proteins, glycoproteins and mucopolysaccharides and in total lipids, glycolipids, phospholipids and gangliosides. Also CNPase, choline acetyltransferase, 5'-nucleotidase and several glycosidases have an altered activity. All these data give a complete neurochemical pattern of the changes underlying the morphological and functional alterations in this disease.

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