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. 1980 Jun;77(6):3539-43.
doi: 10.1073/pnas.77.6.3539.

Predicting coding function from nucleotide sequence or survival of "fitness" of tRNA

G Pieczenik

Predicting coding function from nucleotide sequence or survival of "fitness" of tRNA

G Pieczenik. Proc Natl Acad Sci U S A. 1980 Jun.

Abstract

The sequence of a nucleotide region of f1 bacteriophage was determined on a bonded ultrathin acrylamide gel with a discontinuous buffer system by using the dideoxy-DNA sequencing method. This sequence and one other were analyzed for maximal base pairing with tRNAs. The results allow a prediction of the direction and phase of possible coding functions. The implication of sequence constraints on mRNA codon frequency, tRNA structure, the origin of protein synthesis, and triplet reading are discussed in terms of neutral, Darwinian, and genotypic selectionist perspectives of evolution. The model of F. H. C. Crick, S. Brenner, A. Klug, and G. Pieczenik [(1976) Origins of Life 7, 389-397] for the origin of the genetic code is used to interpet contemporary adaptive and functional nucleic acid sequences.

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