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. 1980 Jun;2(2):99-112.
doi: 10.1007/BF02795837.

Calibration of beam deflection produced by cellular forces in the 10(-9)--10(-6) gram range

E A Evans, R Kwok, T McCown

Calibration of beam deflection produced by cellular forces in the 10(-9)--10(-6) gram range

E A Evans et al. Cell Biophys. 1980 Jun.

Abstract

An experimental procedure and method of analysis are presented for calibration of a thin-beam force transducer. The beam transducer can be produced and calibrated with a minimum coefficient of 10 ng (10(-5) dyne) force per micron (10(-4) cm) deflection, i.e., kB approximately 0.1 dyne/cm. Since beam deflections on the order of 0.1 micron can be detected, forces of a few nanograms can be resolved. Such forces are common in mechanical experiments on microscopic bodies, e.g., biological cells, artificial membrane capsules, droplets, etc.

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References

    1. Exp Cell Res. 1963 Oct;32:59-75 - PubMed
    1. J Exp Biol. 1964 Dec;41:893-906 - PubMed

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