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. 1980 Nov;30(2):607-11.
doi: 10.1128/iai.30.2.607-611.1980.

PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity

R J Daemer, S M Feinstone, J J Alexander, J G Tully, W T London, D C Wong, R H Purcell

PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity

R J Daemer et al. Infect Immun. 1980 Nov.

Abstract

The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did not reveal evidence of synthesis of additional hepatitis B virus markers or of production of infectious virus.

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