Comparative Study
doi: 10.1002/jnr.490050504.
Immunohistochemical localization of the myelin basic protein and of the glial fibrillary acidic protein: comparative study in normal, quaking and jimpy mice
- PMID: 6160256
- DOI: 10.1002/jnr.490050504
Item in Clipboard
Comparative Study
Immunohistochemical localization of the myelin basic protein and of the glial fibrillary acidic protein: comparative study in normal, quaking and jimpy mice
J Neurosci Res.
1980.
Abstract
The topographical distribution of myelin basic protein (MBP) and of glial fibrillary acidic protein (GFA) have been compared in the CNS of 18-day-old normal, quaking, and jimpy mice using indirect immunofluorescence. Comparison was made in brain and spinal cord sections. MBP was strongly decreased in quaking and jimpy mice in all parts of the CNS. A pronounced gliosis was observed in jimpy mice with occurrence of numerous hypertrophied astrocytes. To a lesser extent, an astrocytic reaction was also observed in quaking CNS.
Similar articles
-
Regional distribution of myelin basic protein in the central nervous system of quaking, jimpy, and normal mice during development and aging.J Neurosci Res. 1981;6(3):303-13. doi: 10.1002/jnr.490060305. J Neurosci Res. 1981. PMID: 6170761
-
Accumulation of GFA, the monomeric precursor of the gliofilaments, during development in normal mice and dysmyelinating mutants.J Neurosci Res. 1980;5(5):379-85. doi: 10.1002/jnr.490050503. J Neurosci Res. 1980. PMID: 7192321
-
Order-disorder phenomena in myelinated nerve sheaths. VI. The effects of quaking, jimpy and shiverer mutations: an X-ray scattering study of mouse sciatic and optic nerves.J Mol Biol. 1996 Feb 23;256(2):319-29. doi: 10.1006/jmbi.1996.0088. J Mol Biol. 1996. PMID: 8594199
-
Glycerophosphorylcholine phosphocholine phosphodiesterase activity in cultured oligodendrocytes, astrocytes, and central nervous tissue of dysmyelinating rodent mutants.J Neurosci Res. 1992 Jan;31(1):68-74. doi: 10.1002/jnr.490310110. J Neurosci Res. 1992. PMID: 1319506
-
The biochemistry of myelin in X-linked mutants.Ann N Y Acad Sci. 1990;605:135-45. doi: 10.1111/j.1749-6632.1990.tb42388.x. Ann N Y Acad Sci. 1990. PMID: 1702592 Review. No abstract available.
Cited by
-
Astrocytes in the developing human brain. An immunohistochemical study.Acta Neuropathol. 1986;70(3-4):308-13. doi: 10.1007/BF00686089. Acta Neuropathol. 1986. PMID: 3766128
-
Expression of glial fibrillary acidic protein in the CNS and PNS of murine globoid cell leukodystrophy, the twitcher.Am J Pathol. 1986 Nov;125(2):227-43. Am J Pathol. 1986. PMID: 3538889 Free PMC article.
-
Regional and developmental variations of GFAP and actin mRNA levels in the CNS of jimpy and shiverer mutant mice.J Mol Neurosci. 1993 Summer;4(2):89-96. doi: 10.1007/BF02782121. J Mol Neurosci. 1993. PMID: 8217522
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
