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. 1980 Oct;36(1):115-9.
doi: 10.1128/JVI.36.1.115-119.1980.

Amino acid sequence analysis of reverse transcriptase subunits from avian myeloblastosis virus

T D Copeland, D P Grandgenett, S Oroszlan

Amino acid sequence analysis of reverse transcriptase subunits from avian myeloblastosis virus

T D Copeland et al. J Virol. 1980 Oct.

Abstract

The NH(2)-terminal amino acid sequences of the alpha and beta chains of avian myeloblastosis alphabeta DNA polymerase were determined by using microsequence analysis in the subnanomole range and were found to be identical up to 17 residues. The common sequence was as follows: Thr-Val-Ala-Leu-His-Leu-Ala-Ile-Pro-Leu-Lys-Trp-Lys-Pro-Asn-His-Thr-. This result provides convincing chemical evidence that the alpha chain is derived from the NH(2)-terminal region of the beta chain by proteolytic cleavage, whereas the amino acid composition for these alpha and beta subunits and p32 DNA endonuclease suggests that the latter is derived from the carboxyl-terminal region of the beta chain.

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References

    1. Eur J Biochem. 1967 Mar;1(1):80-91 - PubMed
    1. Biochim Biophys Acta. 1971 Sep 24;246(3):365-83 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Apr;69(4):930-2 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Jan;70(1):230-4 - PubMed
    1. J Biol Chem. 1973 Feb 10;248(3):992-1003 - PubMed

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