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. 1980;24(4):209-17.
doi: 10.1159/000176343.

Oral and parenteral nutrition with L-Valine: mode of action

P Riederer, K Jellinger, G Kleinberger, M Weiser

Oral and parenteral nutrition with L-Valine: mode of action

P Riederer et al. Nutr Metab. 1980.

Abstract

The intravenous application of the branched chain amino acid L-valine to patients with hepatic coma resulted in a specific drop of tryptophan, serotonin and 5-hydroxyindole acetic acid. Clinical improvement of hepatic encephalopathy and of the underlying neurotransmitter (serotonin) and ammonia derangements by administration of L-valine suggest a possible role of this competitive amino acid on intermediary metabolism and ammonia detoxification.

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