Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Oct;77(10):6101-4.
doi: 10.1073/pnas.77.10.6101.

Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system

M L Markert, P Cresswell

Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system

M L Markert et al. Proc Natl Acad Sci U S A. 1980 Oct.

Abstract

The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (alpha) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (beta) or a crossreactive determinant(s) on the HLA-DR3 alpha subunit and an additional alpha subunit. MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.

PubMed Disclaimer

References

    1. Transplant Proc. 1979 Dec;11(4):1764-6 - PubMed
    1. J Exp Med. 1978 Oct 1;148(4):925-39 - PubMed
    1. Eur J Biochem. 1974 Jul 1;46(1):83-8 - PubMed
    1. Cell Immunol. 1977 Feb;28(2):341-54 - PubMed
    1. Nature. 1979 May 31;279(5712):436-7 - PubMed

Publication types