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. 1980 Dec;41(4):815-8.

Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect

A Cooke, P Hutchings, S Marshall-Clarke

Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect

A Cooke et al. Immunology. 1980 Dec.

Abstract

Male and female progeny of a cross between CBA/N female and BALB/c male mice were tested for their ability to generate autoantigen-specific suppressor cells as a result of stimulation with crossreacting rat RBC. Male mice, hemizygous for the X-linked defect, were unable to generate these antigen-specific suppressor cells, whereas their female littermates behaved like the normal (CBA/Ca x BALB/c)F1 mice.

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