Comparative Study
doi: 10.1126/science.6162200.
F-cell production in sickle cell anemia: regulation by genes linked to beta-hemoglobin locus
- PMID: 6162200
- DOI: 10.1126/science.6162200
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Comparative Study
F-cell production in sickle cell anemia: regulation by genes linked to beta-hemoglobin locus
Science.
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Abstract
Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.
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