Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jun 15;188(3):749-55.
doi: 10.1042/bj1880749.

The action of Nupercaine on calcium efflux from rat liver mitochondria

A P Dawson, D V Fulton

The action of Nupercaine on calcium efflux from rat liver mitochondria

A P Dawson et al. Biochem J. .

Abstract

1. Nupercaine inhibits the Ca2+ efflux from rat liver mitochondria observed in the presence of Ruthenium Red, 50% inhibition being obtained at 80 microM-Nupercaine. 2. Neither the Ruthenium Red-stimulated efflux nor its inhibition by Nupercaine can be directly attributed to effects on mitochondrial stability. 3. Nupercaine perturbs the steady-state external Ca2+ concentration in the absence of Ruthenium Red to an extent that is explicable in terms of the inhibition of Ca2+ efflux. 4. Various factors that are likely to be involved in determining steady-state extra-mitochondrial Ca2+ concentrations are discussed.

PubMed Disclaimer

References

    1. J Biol Chem. 1967 Mar 10;242(5):951-7 - PubMed
    1. Arch Biochem Biophys. 1968 Feb;123(2):286-93 - PubMed
    1. Biochim Biophys Acta. 1968 Apr 29;150(3):473-81 - PubMed
    1. Biochemistry. 1969 Jun;8(6):2481-6 - PubMed
    1. Eur J Biochem. 1970 May 1;14(1):120-6 - PubMed