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. 1980 Dec;70(4):555-60.
doi: 10.1111/j.1476-5381.1980.tb09774.x.

Electrically-evoked release of [3H]-histamine from the guinea-pig hypothalamus

M J Biggs, E S Johnson

Electrically-evoked release of [3H]-histamine from the guinea-pig hypothalamus

M J Biggs et al. Br J Pharmacol. 1980 Dec.

Abstract

1 [3H]-histamine was taken up by slices of guinea-pig hypothalamus against a concentration gradient. 2 Electrical field stimulation of the superfused slices resulted in an increased efflux of radioactivity, the major part of which was shown to be associated with histamine by paper chromatography. 3 The evoked release of histamine was dependent on calcium ions in the superfusate and was increased by 56% when the frequency of stimulation was doubled from 5 to 10 Hz.

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