[Fidelity of a polymerization reaction according to the proximity to equilibrium]
[Article in
French]
- PMID: 6162582
Item in Clipboard
[Fidelity of a polymerization reaction according to the proximity to equilibrium]
[Article in
French]
C R Seances Acad Sci D.
.
Abstract
Pyrophosphorolysis, the reverse reaction of nucleotide polymerisation during replication or transcription must influence error-rates. Calculations suggest, for a wide range of reaction mechanisms, a linear dependency between pyrophosphate concentration and the ratio correct/incorrect substrate incorporation. Errors in A.T -rich regions should be particularly sensitive to changes in pyrophosphate concentration.
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