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. 1980 Dec 5;68(3):373-6.
doi: 10.1016/0014-2999(80)90536-1.

Regional 5-HT analysis in Roman high- and low-avoidance rats following MAO inhibition

P Driscoll, J Dedek, J R Martin, K Baettig

Regional 5-HT analysis in Roman high- and low-avoidance rats following MAO inhibition

P Driscoll et al. Eur J Pharmacol. .

Abstract

5-HT and 5-HIAA levels were investigated in three brain regions of Roman high- and low-avoidance rats, following 10, 30 and 60 min of MAO inhibition (pargyline injection). Higher levels of 5-HT in the cortex at 30 and 60 min, as well as a higher disappearance rate of 5-HIAA in the midbrain/medulla region were exhibited by Roman high-avoidance rats, thus further characterizing the differences previously observed in whole brain 5-HT synthesis between these selected rat lines.

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