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. 1980 Aug;95(4):785-95.
doi: 10.1093/genetics/95.4.785.

Translational coupling during expression of the tryptophan operon of Escherichia coli

D S Oppenheim, C Yanofsky

Translational coupling during expression of the tryptophan operon of Escherichia coli

D S Oppenheim et al. Genetics. 1980 Aug.

Abstract

E. coli trpE polar mutations are 10 time more polar on trpD gene expression than on downstream (trpC, B, or A) gene expression. This effects was shown to be the result of "translational coupling," in which efficient translation of trpE-trpD intercistronic punctuation region consists of overlapping stop and start codons, and the trpE and trpD gene products form a functional complex in the cell. In light observations and characteristics, several models for the mechanism of translational coupling are considered.

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References

    1. J Mol Biol. 1966 Nov 14;21(2):313-34 - PubMed
    1. J Mol Biol. 1967 Aug 28;28(1):25-35 - PubMed
    1. Mol Gen Genet. 1970;106(3):208-12 - PubMed
    1. Biochem Biophys Res Commun. 1971 Apr 2;43(1):196-9 - PubMed
    1. JAMA. 1971 Nov 15;218(7):1026-35 - PubMed

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