Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Mar;67(3):878-84.
doi: 10.1172/jci110105.

Heterogeneity of DNA deletion in gamma delta beta-thalassemia

S H Orkin, S C Goff, D G Nathan

Heterogeneity of DNA deletion in gamma delta beta-thalassemia

S H Orkin et al. J Clin Invest. 1981 Mar.

Abstract

By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.

PubMed Disclaimer

References

    1. N Engl J Med. 1972 Jan 20;286(3):129-34 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 - PubMed
    1. Science. 1977 Apr 8;196(4286):161-9 - PubMed
    1. Science. 1977 Apr 8;196(4286):180-2 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1222-6 - PubMed

Publication types

Associated data