doi: 10.1126/science.6163212.
Specific antigen in serum of patients with colon carcinoma
- PMID: 6163212
- DOI: 10.1126/science.6163212
Item in Clipboard
Specific antigen in serum of patients with colon carcinoma
Science.
.
Abstract
The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from patients with other bowel diseases or from healthy volunteers. Of other malignancies studied, serum from two patients with gastric carcinoma and two patients with pancreatic carcinoma also inhibited the specific binding of monoclonal antibody. The levels of carcinoembryonic antigen in these serum samples were not correlated with their levels of binding inhibition. Such monoclonal antibodies may prove useful for the detection of colorectal carcinoma.
Similar articles
-
A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma.Science. 1981 Apr 3;212(4490):55-6. doi: 10.1126/science.7209516. Science. 1981. PMID: 7209516
-
Detection in colorectal carcinoma patients of antibody cytotoxic to established cell strains derived from carcinoma of the human colon and rectum.Int J Cancer. 1975 Jul 15;16(1):16-23. doi: 10.1002/ijc.2910160104. Int J Cancer. 1975. PMID: 51831
-
Murine monoclonal anti-idiotype antibody as a potential network antigen for human carcinoembryonic antigen.J Immunol. 1990 Oct 15;145(8):2758-65. J Immunol. 1990. PMID: 1698862
-
Carcinoembryonic antigens and related glycoproteins. Molecular aspects and specificity.Biochim Biophys Acta. 1983 Dec 29;695(3-4):227-49. doi: 10.1016/0304-419x(83)90013-6. Biochim Biophys Acta. 1983. PMID: 6360209 Review. No abstract available.
-
Carcinoembryonic antigen.Med J Aust. 1972 Jul 8;2(2):91-7. doi: 10.5694/j.1326-5377.1974.tb93525.x. Med J Aust. 1972. PMID: 4561490 Review. No abstract available.
Cited by
-
Localization of antigen defined by anti-scirrhous gastric carcinoma monoclonal antibody S202 in fixed human cancer tissues.Gastroenterol Jpn. 1988 Dec;23(6):619-23. doi: 10.1007/BF02782945. Gastroenterol Jpn. 1988. PMID: 2464522
-
Specificity of tumor markers (CEA, GICA, TPA, alpha-FP, FpA, gamma-GT) for the diagnosis of hepatic metastases from large bowel cancers.Med Oncol Tumor Pharmacother. 1989;6(2):129-32. doi: 10.1007/BF02985235. Med Oncol Tumor Pharmacother. 1989. PMID: 2473362
-
Serum CA19-9 response as a surrogate for clinical outcome in patients receiving fixed-dose rate gemcitabine for advanced pancreatic cancer.Br J Cancer. 2005 Jul 25;93(2):195-9. doi: 10.1038/sj.bjc.6602687. Br J Cancer. 2005. PMID: 15999098 Free PMC article. Clinical Trial.
-
CA125 is superior to CA19-9 in predicting the resectability of pancreatic cancer.J Gastrointest Surg. 2013 Dec;17(12):2092-8. doi: 10.1007/s11605-013-2389-9. Epub 2013 Oct 22. J Gastrointest Surg. 2013. PMID: 24146342
-
Circulating cancer-associated extracellular vesicles as early detection and recurrence biomarkers for pancreatic cancer.Cancer Sci. 2022 Oct;113(10):3498-3509. doi: 10.1111/cas.15500. Epub 2022 Aug 11. Cancer Sci. 2022. PMID: 35848896 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
