Comparative Study
doi: 10.1016/0304-4165(80)90205-6.
Effects of Ca2+ ionophore A23187 and Ca2+ deficiency on pancreatic phospholipids and amylase release in vitro
- PMID: 6163455
- DOI: 10.1016/0304-4165(80)90205-6
Item in Clipboard
Comparative Study
Effects of Ca2+ ionophore A23187 and Ca2+ deficiency on pancreatic phospholipids and amylase release in vitro
Biochim Biophys Acta.
.
Abstract
The Ca2+ ionophore A23187 elicits a transient increase in pancreatic amylase release in vitro, and this is accompanied by a transient decrease in phosphatidyl inositol concentration. Effects of ionophore A23187 and carbachol on amylase release and phosphatidylinisitol breakdown are dependent on medium Ca2+. These results suggest that major secretagogue-induced, pancreatic phospholipid changes follow, rather than precede, changes in Ca2+ in the pancreas.
Similar articles
-
Effects of carbachol and pancreozymin (cholecystokinin-octapeptide) on polyphosphoinositide metabolism in the rat pancreas in vitro.Biochem J. 1984 Jan 1;217(1):281-7. doi: 10.1042/bj2170281. Biochem J. 1984. PMID: 6199018 Free PMC article.
-
Effects of the calcium ionophore A23187 on pancreatic acinar cell membrane potentials and amylase release.J Physiol. 1977 Jan;264(2):323-39. doi: 10.1113/jphysiol.1977.sp011671. J Physiol. 1977. PMID: 320310 Free PMC article.
-
Insulin and its secretagogues activate Ca2+-dependent phosphatidylinositol breakdown and amylase secretion in rat pancreas in vitro.Diabetes. 1981 May;30(5):396-401. doi: 10.2337/diab.30.5.396. Diabetes. 1981. PMID: 6164587
-
The effect of the ionophore A23187 on amylase release, cellular integrity and ultrastructure of mouse pancreatic acini.Cell Tissue Res. 1978 Jan 17;186(2):287-95. doi: 10.1007/BF00225538. Cell Tissue Res. 1978. PMID: 342104
-
Clinical significance and experimental studies on amylase. A review.Indian J Med Sci. 1966 Mar;20(3):181-93. Indian J Med Sci. 1966. PMID: 5325832 Review. No abstract available.
Cited by
-
Effects of carbachol and pancreozymin (cholecystokinin-octapeptide) on polyphosphoinositide metabolism in the rat pancreas in vitro.Biochem J. 1984 Jan 1;217(1):281-7. doi: 10.1042/bj2170281. Biochem J. 1984. PMID: 6199018 Free PMC article.
-
Calcium in the regulation of gravitropism by light.Plant Physiol. 1988;86(4):1276-80. doi: 10.1104/pp.86.4.1276. Plant Physiol. 1988. PMID: 11538230 Free PMC article.
-
Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets.J Clin Invest. 1983 Jul;72(1):13-21. doi: 10.1172/jci110951. J Clin Invest. 1983. PMID: 6192142 Free PMC article.
-
Phospholipid turnover in isolated rat pancreatic acini. Consideration of the relative roles of phospholipase A2 and phospholipase C.Biochem J. 1982 Dec 15;208(3):713-21. doi: 10.1042/bj2080713. Biochem J. 1982. PMID: 6819865 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
