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. 1980 Aug;29(2):301-5.
doi: 10.1128/iai.29.2.301-305.1980.

Interferon immunosuppression: mediation by a suppressor factor

H M Johnson, J E Blalock

Interferon immunosuppression: mediation by a suppressor factor

H M Johnson et al. Infect Immun. 1980 Aug.

Abstract

Suppression of the in vitro antibody response to sheep erythrocytes by mouse fibroblast interferon occurred by induction of suppressor cell activity in spleen cells. The suppressor cells produced a soluble factor which mediated the immunosuppression. The suppressor factor did not inhibit virus replication; thus, interferon probably regulates the B-cell response by a mechanism that is different from its antiviral effect.

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