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. 1980 Aug;29(2):561-3.
doi: 10.1128/iai.29.2.561-563.1980.

Human immune interferon: induction in lymphoid cells by a calcium ionophore

F Dianzani, T M Monahan, J Georgiades, J B Alperin

Human immune interferon: induction in lymphoid cells by a calcium ionophore

F Dianzani et al. Infect Immun. 1980 Aug.

Abstract

Human lymphocyte cultures produced interferon after treatment with the calcium ionophore A23187, but not after treatment with potassium ionophore nonactin. Interferon production was detectable between 3 and 6 h after ionophore treatment and reached the maximum level between 12 and 24 h. Ionophore-induced interferon appeared to be immune interferon on the basis of acid lability, lack of neutralization by antibody to leukocyte interferon, slow kinetics of activation of the antiviral state, and molecular characterization by isoelectrofocusing.

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