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. 1981 Feb 11;9(3):731-41.
doi: 10.1093/nar/9.3.731.

Bacterial synthesis of a novel human leukocyte interferon

E Yelverton, D Leung, P Weck, P W Gray, D V Goeddel
Free PMC article

Bacterial synthesis of a novel human leukocyte interferon

E Yelverton et al. Nucleic Acids Res. .
Free PMC article

Abstract

A novel human leukocyte interferon cDNA clone (LeIF B) was identified in a cDNA library prepared using polyadenylated mRNA of a myeloblastoid cell line. The nucleotide sequence of LeIF B differs significantly from other published leukocyte interferon cDNA sequences. An expression plasmid was constructed which directs the synthesis in E. coli of 8 x 10(7) interferon units per liter of culture. LeIF B exhibits markedly different specificities from another bacterially synthesized human leukocyte interferon, LeIF A.

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References

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