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. 1981 Mar 30;209(2):464-9.
doi: 10.1016/0006-8993(81)90171-2.

Reduction in basal ganglia and substantia nigra substance P levels in Huntington's disease

S H Buck, T F Burks, M R Brown, H I Yamamura

Reduction in basal ganglia and substantia nigra substance P levels in Huntington's disease

S H Buck et al. Brain Res. .

Abstract

Substance P (SP) levels were determined by radioimmunoassay (RIA) in several regions of post-mortem brain of controls and Huntington's disease (HD) patients. In controls, highest SP levels were found in basal ganglia, substantia nigra and hypothalamus. Nigral pars reticulata contained 3--4-fold higher levels than pars compacta. In HD, SP levels were reduced in all basal ganglia and substantia nigra. The reductions ranged from 48% in caudate nucleus to over 90% in nigral pars reticulata. There were no changes in SP levels in HD frontal cortex, thalamus or hypothalamus.

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