Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Mar;37(3):845-53.
doi: 10.1128/JVI.37.3.845-853.1981.

Antigenic drift in the hemagglutinin of the Hong Kong influenza subtype: correlation of amino acid changes with alterations in viral antigenicity

M J Sleigh, G W Both, P A Underwood, V J Bender

Antigenic drift in the hemagglutinin of the Hong Kong influenza subtype: correlation of amino acid changes with alterations in viral antigenicity

M J Sleigh et al. J Virol. 1981 Mar.

Abstract

The nucleotide sequence of the gene coding for the large subunit of influenza virus hemagglutinin (HA1) was determined for strains A/NT/60/68, A/Eng/878/69, and A/Qu/7/70, three early isolates of the Hong Kong subtype. Sequences were obtained by the dideoxy chain termination method, using reverse transcriptase to synthesize partial DNA copies of the RNA gene. HA1 amino acid sequences predicted from the gene sequences were compared with published data for strains A/Aichi/2/68 and A/Vic/3/75. Compared with earlier strains, the HA1s of A/eng/878/69 and A/Qu/7/70 each contained three amino acid changes. Some of these were also found in A/Vic/3/75, but some were unique to the particular strain. When all of the strains were titrated with a panel of monoclonal antibodies directed against A/NT/60/68, alterations in viral antigenicity could be correlated with particular amino acid changes. The existence of multiple pathways for viral evolution during antigenic drift is discussed.

PubMed Disclaimer

References

    1. J Exp Med. 1966 Sep 1;124(3):331-45 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. J Virol. 1973 Feb;11(2):183-92 - PubMed
    1. C R Acad Sci Hebd Seances Acad Sci D. 1973 Mar 19;276(12):1917-20 - PubMed
    1. Eur J Immunol. 1976 Jul;6(7):511-9 - PubMed

Associated data