doi: 10.1016/0006-8993(81)90980-x.
A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat
- PMID: 6165438
- DOI: 10.1016/0006-8993(81)90980-x
Item in Clipboard
A re-evaluation of the neurochemical and antinociceptive effects of intrathecal capsaicin in the rat
Brain Res.
.
Abstract
The effect of intrathecal administration of capsaicin in the rat on thermal nociceptive thresholds and on the content of substance P, somatostatin and glutamic acid decarboxylase in the dorsal horn of the spinal cord was determined. The results suggest that the depletion of spinal cord substance P induced by capsaicin may not by itself be sufficient to explain the observed changes in noxious thermal thresholds, which may be related instead to non-specific damage to the spinal cord.
Similar articles
-
Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.Science. 1979 Oct 26;206(4417):481-3. doi: 10.1126/science.228392. Science. 1979. PMID: 228392
-
Neurotoxic action of capsaicin on spinal substance P neurons.Brain Res. 1980 Mar 31;186(2):435-44. doi: 10.1016/0006-8993(80)90987-7. Brain Res. 1980. PMID: 6153557
-
Capsaicin does not change tissue levels of glutamic acid, its uptake, or release in the rat spinal cord.J Neurochem. 1982 May;38(5):1383-6. doi: 10.1111/j.1471-4159.1982.tb07916.x. J Neurochem. 1982. PMID: 6174698
-
Effect of capsaicin administration to neonatal rats on the substance P content of discrete CNS regions.Brain Res. 1981 Oct 19;222(2):428-31. doi: 10.1016/0006-8993(81)91049-0. Brain Res. 1981. PMID: 6169396
-
Effects of capsaicin on nociceptive heat, pressure and chemical thresholds and on substance P levels in the rat.Brain Res. 1980 May 12;189(2):561-4. doi: 10.1016/0006-8993(80)90369-8. Brain Res. 1980. PMID: 6154506 No abstract available.
Cited by
-
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation.Mol Cell Neurosci. 2010 Jan;43(1):157-63. doi: 10.1016/j.mcn.2009.10.006. Epub 2009 Oct 21. Mol Cell Neurosci. 2010. PMID: 19853036 Free PMC article.
-
Emerging Role of Spinal Cord TRPV1 in Pain Exacerbation.Neural Plast. 2016;2016:5954890. doi: 10.1155/2016/5954890. Epub 2016 Jan 14. Neural Plast. 2016. PMID: 26885404 Free PMC article. Review.
-
Capsaicin and nociception in the rat and mouse. Possible role of substance P.Naunyn Schmiedebergs Arch Pharmacol. 1982 Sep;320(3):205-16. doi: 10.1007/BF00510129. Naunyn Schmiedebergs Arch Pharmacol. 1982. PMID: 6182473
-
Desensitization to substance P following intrathecal injection. A technique for investigating the role of substance P in nociception.Naunyn Schmiedebergs Arch Pharmacol. 1985 Nov;331(2-3):152-8. doi: 10.1007/BF00634232. Naunyn Schmiedebergs Arch Pharmacol. 1985. PMID: 2418368
-
Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro.Naunyn Schmiedebergs Arch Pharmacol. 1982 Apr;319(1):78-81. doi: 10.1007/BF00491482. Naunyn Schmiedebergs Arch Pharmacol. 1982. PMID: 6180329
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
