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. 1981 Jul 1;48(1):5-9.
doi: 10.1002/1097-0142(19810701)48:1<5::aid-cncr2820480103>3.0.co;2-c.

Combined interferon--antimetabolite therapy of murine L1210 leukemia

L M Slater, M W Wetzel, T Cesario

Combined interferon--antimetabolite therapy of murine L1210 leukemia

L M Slater et al. Cancer. .

Abstract

To assess the interaction of interferon with estabished chemotherapeutic agents, L1210 murine leukemia in BDF/1 mice was treated with methotrexate, 6-mercaptopurine. Adriamycin, cytosine arabinoside or cyclophosphamide alone or in combination with mouse L-cell (Newcastle disease virus-induced) interferon or with interferon-free tissue culture medium. Also studied was the effect of interferon on the combined 6-mercaptopurine-methotrexate therapy of this tumor. Interferon failed to enhance the response of L1210 leukemia to 6-mercaptopurine, adriamycin, cytosine arabinoside or cyclophosphamide. The addition of interferon to all methotrexate-containing regimens increased mean survival time (P less than 0.05). The increase in survival of host animals treated with 6-mercaptopurine-methotrexate and interferon was sustained though four transfer generations despite evolving resistance to this antimetabolite combination.

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