doi: 10.1016/0014-2999(81)90387-3.
In vitro release of substance P from spinal cord slices by capsaicin congeners
- PMID: 6165593
- DOI: 10.1016/0014-2999(81)90387-3
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In vitro release of substance P from spinal cord slices by capsaicin congeners
Eur J Pharmacol.
.
Abstract
The in vitro release of immunoreactive substance P (I-SP) by capsaicin and three congeners was studied on slices of rat spinal cord upper dorsal horn. Capsaicin and its congeners were all able to stimulate I-SP release, indicating that they act on chemosensitive primary afferents terminating in this region. A positive correlation was found between the I-SP releasing and pain-producing potencies of these compounds. This is in agreement with the concept that primary afferents containing substance P (SP) are involved in the transmission of nociceptive information.
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