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. 1981 May 15;37(5):521-3.
doi: 10.1007/BF01986174.

Antidiuretic activities of substance P and its analogs

M Ukai, T Nagase, M Hirohashi, N Yanaihara

Antidiuretic activities of substance P and its analogs

M Ukai et al. Experientia. .

Abstract

Substance P (SP) and analogs, including 5 nucleoside (ARA or HRA)-peptides, were examined for antidiuretic activity in ethanolized rats. The activity was potent in the analogs embodying the C-terminal hexapeptide, weak in the nucleoside-pentapeptide, and negligible in the nucleoside-tetrapeptide. In addition, the activity was increased by acylation of the hexapeptide. The antidiuretic potencies were also compared with the hypotensive potencies.

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