Inactivation of human interferon by body fluids
- PMID: 616673
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Inactivation of human interferon by body fluids
Tex Rep Biol Med.
1977.
Abstract
We have shown almost all samples of serum, saliva, cerebrospinal fluid, fecal extract, bile or urine tested contain a substance or substances capable of inactivating human interferon at normal body temperature. This adverse effect appears to be greater for fibroblast interferon-induced by either polynucleotides or viruses, than for leukocyte interferon induced by viruses. These results have a number of implications for the clinical utilization of this natural antiviral substance.
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