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. 1977:35:443-8.

Inactivation of human interferon by body fluids

T C Cesario, J G Tilles
  • PMID: 616673

Inactivation of human interferon by body fluids

T C Cesario et al. Tex Rep Biol Med. 1977.

Abstract

We have shown almost all samples of serum, saliva, cerebrospinal fluid, fecal extract, bile or urine tested contain a substance or substances capable of inactivating human interferon at normal body temperature. This adverse effect appears to be greater for fibroblast interferon-induced by either polynucleotides or viruses, than for leukocyte interferon induced by viruses. These results have a number of implications for the clinical utilization of this natural antiviral substance.

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