[Phospholipid metabolism in acetylcholine and substance P induced desensitization of guinea pig ileum smooth muscle]

Abstract

The amount and the rate of inorganic phosphate incorporation into mono-, di- and triphosphoinositides and into total phospholipids of ileum smooth muscle were studied at various time of exposure to physiological concentrations of acetylcholine and substance P. The data obtained show a phase character of the mediator influence on the phosphate incorporation into mono and triphosphoinositides-a stimulation initial period, an inhibition during the desensitization period and a return to the normal level after the mediator elimination.