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Comparative Study
. 1981 May;11(3):184-92.
doi: 10.1007/BF01967612.

Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells

F De Clerck, J Van Reempts, M Borgers
Comparative Study

Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells

F De Clerck et al. Agents Actions. 1981 May.

Abstract

Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release by n-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187.

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