A theoretical approach to the analysis of axonal transport

Abstract

A theoretical model of intra-axonal transport is proposed that presupposes a carrier system moving down the axon in a distal direction. Protein and particle transport is achieved by their reversible association with the distally moving carriers. Mathematical equations representing the concentrations of moving carriers and proteins and/or particles within the axon at any position and time are proposed. Analysis of the equations demonstrates that a traveling wave solution for the particle concentration (an experimental fact) is possible provided the chemical interaction between particles and carriers exhibits positive cooperativity. The phase velocity of the wave solution is interpreted as the observed velocity of the intra-axonal transport, known to be independent of position of observation. In addition, the theory predicts a spectrum of transport velocities for different proteins, in agreement with observations. The velocity of a given protein is dependent on its affinity to the carrier.