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. 1981 Mar;3(1):89-104.
doi: 10.1007/BF02782155.

A general interactive model for B cell activation II. Experimental verification

A J Rosenspire, D M Jacobs

A general interactive model for B cell activation II. Experimental verification

A J Rosenspire et al. Cell Biophys. 1981 Mar.

Abstract

The general interactive model described in the previous paper was subjected to experimental testing. We examined the high affinity anti-TNP plaque-forming cell response of cultures of murine lymphocytes exposed to lipopolysaccharide and trinitrophenylated lipopolysaccharide (TNP--LPS). From our model we predicted the effects of the addition of free LPS on the dose response to TNP--LPS, the effect of the addition of Polymyxin B to cultures stimulated with TNP--LPS, and the effect on the response to TNP--LPS preparations with different haptenation ratios. The results obtained were consistent with the predictions of the general interactive model.

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