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. 1977;36(11-12):1927-30.

Inactivation studies of cathepsin D with diazo compounds

I Kregar, B Stanovnik, M Tisler, C Nisi, F Gubensek, V Turk
  • PMID: 616738

Inactivation studies of cathepsin D with diazo compounds

I Kregar et al. Acta Biol Med Ger. 1977.

Abstract

Cathepsin D was inactivated with various diazo compounds at very high concentration. Reaction proceeded maximally at pH 4.5 in the presence of cupric ions. With 3-diazo-indazole and triazene the inactivation was noted also in the absence of cupric ions what indicates that the mechanism is mediated through triazene. CD-spectrum of partially inactivated enzyme shows that conformational changes occurred after treatment with diazo compound.

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