Inhibition of serine proteinases by benzamidine derivatives
- PMID: 616739
Item in Clipboard
Inhibition of serine proteinases by benzamidine derivatives
Acta Biol Med Ger.
1977.
Abstract
Derivatives of benzamidine inhibit competitively the activity of the serine proteinases trypsin, plasmin, thrombin, and of the clotting factor Xa. The inhibitor activities (Ki-values) of various benzamidine derivatives against the several enzymes were compared. Besides parallels, deviations in the corresponding structure-activity relationships were found. From these results it is concluded that the similar enzymes exhibit certain differences in the structure of the primary and secondary binding sites.
Similar articles
-
Are factor Xa inhibitors superior to thrombin inhibitors in anticoagulation?Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(1-2):152-6. Folia Haematol Int Mag Klin Morphol Blutforsch. 1988. PMID: 2459011
-
Inhibition of acrosin by benzamidines.Acta Biol Med Ger. 1981;40(10-11):1519-22. Acta Biol Med Ger. 1981. PMID: 7044006
-
Aromatic tetra-amidines: antiproteolytic and antiesterolytic activities towards serine proteinases involved in blood coagulation and clot lysis.Farmaco Sci. 1986 Jun;41(6):464-70. Farmaco Sci. 1986. PMID: 3527742
-
Interactions of thrombin with benzamidine-based inhibitors.Biol Chem Hoppe Seyler. 1992 Jul;373(7):491-6. doi: 10.1515/bchm3.1992.373.2.491. Biol Chem Hoppe Seyler. 1992. PMID: 1515080 Review.
-
Current concepts on action of synthetic thrombin inhibitors.Haemostasis. 1978;7(2-3):170-6. doi: 10.1159/000214258. Haemostasis. 1978. PMID: 350730 Review.
Cited by
-
Degradation of human epidermal keratin by cod trypsin and extracts of fish intestines.Arch Dermatol Res. 1989;280(8):469-73. doi: 10.1007/BF00427658. Arch Dermatol Res. 1989. PMID: 2465741