The diversity of cellular proteinases in physiology and pathology
- PMID: 616744
The diversity of cellular proteinases in physiology and pathology
Abstract
1. It is suggested that the functions of cellular proteinases are far more diverse than has usually been realized. 2. A scheme is proposed in which isolation of a pure proteinase leads to a rather detailed exploration of its biological significance. 3. Representative proteinases from the serine, thiol, carboxyl and metallo-classes are briefly reviewed with emphasis on the relationship between improved understanding at the molecular level and eventual progress in the understanding of some important physiological and pathological processes. 4. An attempt is made to forsee future developments in this area of biochemistry, in terms of both new trends in research, and the eventual application of knowledge of the proteinases to medical problems.
Similar articles
-
The many forms and functions of cellular proteinases.Fed Proc. 1980 Jan;39(1):9-14. Fed Proc. 1980. PMID: 6985872 Review.
-
Proteinases in cardiac and skeletal muscle.Fed Proc. 1980 Jan;39(1):20-5. Fed Proc. 1980. PMID: 6985869 Review.
-
Protein degradation in health and disease. Introduction: the classification of proteinases.Ciba Found Symp. 1979;(75):1-13. Ciba Found Symp. 1979. PMID: 233352 Review.
-
Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell.J Immunol. 1990 Oct 15;145(8):2652-61. J Immunol. 1990. PMID: 2212656
-
Diversity of digestive proteinases in Tenebrio molitor (Coleoptera: Tenebrionidae) larvae.Comp Biochem Physiol B Biochem Mol Biol. 2006 Oct;145(2):126-37. doi: 10.1016/j.cbpb.2006.05.005. Epub 2006 May 23. Comp Biochem Physiol B Biochem Mol Biol. 2006. PMID: 16859942