doi: 10.1016/0198-8859(80)90005-1.
Genetic mapping of the hemochromatosis locus on chromosome six
- PMID: 6167540
- DOI: 10.1016/0198-8859(80)90005-1
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Genetic mapping of the hemochromatosis locus on chromosome six
Hum Immunol.
1980 Jul.
Abstract
The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, B7 and A28, B12 haplotypes. The hemochromatosis locus segregated with the HLA-A locus and not with the HLA-B locus. Thus, the hemochromatosis locus maps in close proximity to the HLA-A locus.
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