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. 1980 Jul;1(1):19-22.
doi: 10.1016/0198-8859(80)90005-1.

Genetic mapping of the hemochromatosis locus on chromosome six

C Q Edwards, G E Cartwright, M H Skolnick, D B Amos

Genetic mapping of the hemochromatosis locus on chromosome six

C Q Edwards et al. Hum Immunol. 1980 Jul.

Abstract

The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, B7 and A28, B12 haplotypes. The hemochromatosis locus segregated with the HLA-A locus and not with the HLA-B locus. Thus, the hemochromatosis locus maps in close proximity to the HLA-A locus.

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