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. 1981;51(1-2):83-96.
doi: 10.1007/BF01664006.

Neuropeptides in striato-nigral pathways

A C Cuello, M Del Fiacco, G Paxinos, P Somogyi, J V Priestley

Neuropeptides in striato-nigral pathways

A C Cuello et al. J Neural Transm. 1981.

Abstract

The existence of a neuronal pathway containing Leu-enkephalin and connecting the neostriatum with the globus pallidus has been confirmed combining immunohistochemistry with microinjections of neurotoxic agents (kainic acid, colchicine) and discrete knife lesions. The presence of substance P in nerve terminals of the substantia nigra was demonstrated by the application of a monoclonal antibody against this peptide. Electron microscopic studies revealed immunoreactive sites for substance P in nerve terminals establishing symmetric and asymmetric synapses, mainly over dendritic profiles. The possible peptide-containing neuronal pathways in the nigro-striatal system are discussed.

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References

    1. Brain Res. 1977 Oct 14;134(3):393-405 - PubMed
    1. J Comp Neurol. 1978 Jul 15;180(2):301-23 - PubMed
    1. Med Biol. 1974 Dec;52(6):424-7 - PubMed
    1. Nature. 1980 Jun 12;285(5765):476-8 - PubMed
    1. Adv Neurol. 1976;14:7-48 - PubMed

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