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. 1981;225(3):183-7.
doi: 10.1007/BF00313747.

Huntington's chorea-- measurements of somatostatin, substance P and cyclic nucleotides in the cerebrospinal fluid

H Cramer, J Kohler, G Oepen, G Schomburg, E Schröter

Huntington's chorea-- measurements of somatostatin, substance P and cyclic nucleotides in the cerebrospinal fluid

H Cramer et al. J Neurol. 1981.

Abstract

Somatostatin, substance P, cyclic AMP and cyclic GMP were determined in the cerebrospinal fluid of patients with Huntington's disease, in first generation relatives of choreic patients and in neurological control patients. Substance P levels were not significantly altered, but somatostatin levels were markedly decreased both in affected patients and symptom-free offspring. Cyclic AMP was decreased only in patients with advanced stages of the disease while cyclic GMP was normal. Evidence is discussed which may support a role of somatostatin deficiency in the pathophysiology of chorea.

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References

    1. Anal Biochem. 1976 Jan;70(1):195-202 - PubMed
    1. Eur Neurol. 1975;13(2):123-30 - PubMed
    1. Brain. 1980 Mar;103(1):179-210 - PubMed
    1. Neurosci Lett. 1979 Nov;15(1):65-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9 - PubMed

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