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. 1981 Jul 15;37(7):755-6.
doi: 10.1007/BF01967963.

A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors

H Nawrath, P Gruschwitz, X Zong

A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors

H Nawrath et al. Experientia. .

Abstract

The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect in unrelated to beta-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.

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References

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