doi: 10.1007/BF01967963.
A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors
- PMID: 6168488
- DOI: 10.1007/BF01967963
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A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors
Experientia.
.
Abstract
The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect in unrelated to beta-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.
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