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. 1981 Jun;34(6):658-64.
doi: 10.7164/antibiotics.34.658.

Tallysomycin, a new antitumor antibiotic complex related to bleomycin. IV. New biosynthetic derivatives of tallysomycin

T Miyaki, O Tenmyo, K Numata, K Matsumoto, H Yamamoto, Y Nishiyama, M Ohbayashi, H Imanishi, M Konishi, H Kawaguchi
Free article

Tallysomycin, a new antitumor antibiotic complex related to bleomycin. IV. New biosynthetic derivatives of tallysomycin

T Miyaki et al. J Antibiot (Tokyo). 1981 Jun.
Free article

Abstract

A series of new biosynthetic derivatives of tallysomycins A and B were obtained by precursor amine-feeding fermentation. Certain diamines were incorporated into tallysomycins as the terminal amine moiety affording two classes of biosynthetic derivatives, with or without the Beta-lysine moiety in the subterminal position. Among 21 derivatives prepared, tallysomycin S10b was selected for further studies in view of its favorable therapeutic indices.

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