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. 1981 Oct 16;214(4518):270-4.
doi: 10.1126/science.6169150.

Automated synthesis of gene fragments

G Alvarado-Urbina, G M Sathe, W C Liu, M F Gillen, P D Duck, R Bender, K K Ogilvie

Automated synthesis of gene fragments

G Alvarado-Urbina et al. Science. .

Abstract

The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.

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