Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Aug;20(2):272-4.
doi: 10.1128/AAC.20.2.272.

Sodium polyanethol sulfonate inactivation of aminoglycosides

D J Krogstad, P R Murray, G G Granich, A C Niles, J H Ladenson, J E Davis

Sodium polyanethol sulfonate inactivation of aminoglycosides

D J Krogstad et al. Antimicrob Agents Chemother. 1981 Aug.

Abstract

Sodium polyanethol sulfonate and another polyanion (dextran sulfate) both inhibited aminoglycoside activity in vitro. This effect was not produced by an otherwise similar neutral carbohydrate (dextran) or by neutral detergents (Brij-35, Triton X-100) but was antagonized by an anion-exchange resin (Dowex 1X8-50). We conclude that the inactivation of aminoglycosides by sodium polyanethol sulfonate results from its polyanionic nature and is unrelated to its detergent properties.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Experientia. 1969 Nov 15;25(11):1184-5 - PubMed
    1. Appl Microbiol. 1970 Sep;20(3):465-8 - PubMed
    1. J Infect Dis. 1971 Dec;124 Suppl:S90-5 - PubMed
    1. Appl Microbiol. 1972 Nov;24(5):691-8 - PubMed
    1. Appl Microbiol. 1974 Jun;27(6):1131-3 - PubMed

MeSH terms